Forensic DNA Analysis

Forensic DNA Analysis: Tracing Genetic Codes for Law

Forensic DNA analysis involves the investigation of DNA samples in order to identify persons and establish biological relationships. Genetic profiles from crime scenes, victims, and suspects are compared, providing vital evidence for criminal investigations and legal actions to confirm or dismiss prospective culprits.
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Overview

Forensic DNA analysis stands as a pivotal pillar in modern forensic science, revolutionizing the way criminal investigations are conducted. Since its inception, this technique has played a crucial role in solving crimes, identifying perpetrators, and exonerating the innocent. The power of DNA lies in its uniqueness – the blueprint of life, encoding information that differentiates individuals. This article by Academic Block examines the intricacies of forensic DNA analysis, exploring its history, methodologies, applications, and the ethical considerations surrounding this groundbreaking field.

Historical Perspective

The roots of forensic DNA analysis can be traced back to the landmark case of Colin Pitchfork in the mid-1980s. Pitchfork became the first person to be convicted using DNA evidence in 1988 for the rape and murder of two young girls in Leicestershire, England. This watershed moment marked the beginning of a new era in forensic science, highlighting the potential of DNA analysis to revolutionize criminal investigations.

Basics of DNA

Deoxyribonucleic acid, commonly known as DNA, is the hereditary material present in the cells of all living organisms. Structurally, DNA is composed of nucleotides, which in turn consist of a sugar molecule, a phosphate group, and one of four nitrogenous bases – adenine (A), thymine (T), cytosine (C), and guanine (G). The unique sequence of these bases forms the genetic code that distinguishes one individual from another.

Methodologies in Forensic DNA Analysis

  1. DNA Extraction: The first step in forensic DNA analysis involves extracting DNA from biological samples found at crime scenes. Common sources of DNA include blood, semen, hair, saliva, and tissue. DNA extraction techniques vary depending on the nature of the sample and may involve chemical processes, enzymatic reactions, or mechanical methods.

  2. Polymerase Chain Reaction (PCR): Once extracted, the amount of DNA available for analysis is often limited. Polymerase Chain Reaction (PCR) is a revolutionary technique that allows forensic scientists to amplify small DNA samples, making them suitable for analysis. PCR involves the repeated replication of specific DNA segments, creating millions of copies for further examination.

  3. Short Tandem Repeat (STR) Analysis: Short Tandem Repeats (STRs) are specific DNA sequences that vary in length among individuals. STR analysis is a cornerstone of forensic DNA profiling. By identifying the number of repeats at multiple loci, forensic analysts can create a unique genetic profile for each individual. The high variability of STRs contributes to the robustness and reliability of this technique.

  4. DNA Sequencing: Advancements in technology have led to the integration of DNA sequencing in forensic analysis. While traditional methods focused on analyzing specific regions of the genome, DNA sequencing allows for the examination of an individual's entire DNA sequence. Next-generation sequencing technologies have significantly increased the speed and accuracy of this process.

Applications of Forensic DNA Analysis

  1. Crime Scene Investigations: Forensic DNA analysis is routinely employed to link suspects to crime scenes or victims. DNA evidence collected from bloodstains, hair follicles, or other biological materials can provide crucial leads, helping investigators establish the presence of specific individuals at the scene.

  2. Paternity and Relationship Testing: DNA analysis is widely used for determining paternity and establishing biological relationships. In legal contexts, such as child custody cases, inheritance disputes, or immigration proceedings, DNA testing can provide definitive answers regarding familial connections.

  3. Missing Persons and Cold Cases: Forensic DNA analysis has been instrumental in solving missing persons cases and resurrecting cold cases. By comparing DNA profiles obtained from unidentified remains with databases of known individuals, authorities can potentially identify long-lost individuals or victims.

  4. Mass Disasters and Humanitarian Efforts: In cases of mass disasters, natural calamities, or armed conflicts, forensic DNA analysis plays a vital role in identifying victims. This has significant implications in humanitarian efforts, allowing for the repatriation of remains to their families for proper burial.

Challenges and Ethical Considerations

  1. Contamination and Degradation: One of the primary challenges in forensic DNA analysis is the potential for contamination or degradation of samples. Proper handling and preservation techniques are crucial to ensure the integrity of DNA evidence. Contamination can lead to false results and compromise the reliability of the analysis.

  2. Privacy Concerns: The increasing use of DNA databases, both in criminal investigations and for genealogical purposes, raises concerns about privacy. Individuals may unknowingly contribute their genetic information to databases when participating in commercial DNA testing services, and the potential misuse of this data is a subject of ethical debate.

  3. Racial and Ethnic Bias: Forensic DNA analysis may be subject to biases based on racial or ethnic factors. The representation of diverse populations in DNA databases is essential to avoid disparities in the accuracy and fairness of forensic results.

Future Trends and Innovations

  1. Advanced Sequencing Technologies: The continuous evolution of sequencing technologies promises faster and more accurate results. The advent of third-generation sequencing, nanopore sequencing, and other innovations holds the potential to further enhance forensic DNA analysis capabilities.

  2. Artificial Intelligence in DNA Analysis: The integration of artificial intelligence (AI) and machine learning in forensic DNA analysis is on the horizon. These technologies can assist in pattern recognition, data analysis, and the interpretation of complex genetic information, speeding up the investigative process.

  3. Rapid DNA Analysis: Efforts are underway to develop portable and rapid DNA analysis tools that can provide on-site results within minutes. These advancements could revolutionize crime scene investigations, allowing law enforcement to make immediate decisions based on DNA evidence.

Final Words

Forensic DNA analysis has undeniably transformed the landscape of criminal investigations, providing unparalleled insights into human identity and relationships. From its humble beginnings in the 1980s to the sophisticated methodologies of today, this field continues to evolve, promising even greater accuracy and efficiency in the future. As technology advances and ethical considerations are addressed, forensic DNA analysis remains a powerful tool in the pursuit of justice, offering hope to victims, closure to families, and a deterrent to those who would perpetrate crime.Please provide your views in comment section to make this article better. Thanks for Reading!

This Article will answer your questions like:

+ What is forensic DNA analysis? >

Forensic DNA analysis is a technique used to identify individuals by examining their unique DNA profiles. This method involves extracting and analyzing DNA from biological samples, such as blood, hair, or tissues, to match evidence from crime scenes with suspects or victims.

+ What are the 4 steps in forensic DNA analysis? >

The four steps in forensic DNA analysis are: (1) Sample Collection – gathering biological samples from crime scenes. (2) DNA Extraction – isolating DNA from these samples. (3) DNA Amplification – using techniques like PCR to increase DNA quantity. (4) DNA Profiling – analyzing and comparing DNA profiles to identify individuals or link evidence to suspects.

+ What are the methods used in forensic analysis of DNA? >

Methods used in forensic DNA analysis include Polymerase Chain Reaction (PCR) for amplifying DNA, Short Tandem Repeat (STR) analysis for profiling, and DNA sequencing for detailed examination. Additional techniques like RFLP (Restriction Fragment Length Polymorphism) and SNP (Single Nucleotide Polymorphism) analysis are used to provide detailed genetic information and improve accuracy in matching DNA profiles.

+ What are the 4 types of DNA analysis? >

The four types of DNA analysis are: (1) Short Tandem Repeat (STR) Analysis – examines specific areas of DNA for identification. (2) Restriction Fragment Length Polymorphism (RFLP) – analyzes variations in DNA fragment lengths. (3) DNA Sequencing– determines the exact sequence of nucleotides in DNA. (4) Mitochondrial DNA Analysis – studies DNA from mitochondria, useful for degraded samples.

+ How does forensic DNA analysis contribute to criminal investigations? >

Forensic DNA analysis contributes to criminal investigations by providing a means to accurately identify or exclude individuals based on DNA profiles. It helps link suspects to crime scenes, verify alibis, and match evidence from crime scenes with victims or suspects.

+ What are the basic principles of DNA and how is it utilized in forensic analysis? >

The basic principles of DNA involve its role as the blueprint for genetic information, with each individual having a unique DNA profile. In forensic analysis, DNA is extracted from biological samples and compared against known profiles to identify or exclude individuals.

+ What role did the Colin Pitchfork case play in the history of forensic DNA analysis? >

The Colin Pitchfork case was pivotal in the history of forensic DNA analysis as it was the first case where DNA profiling was used to convict a criminal. In 1988, DNA evidence helped identify Pitchfork as the perpetrator of two murders in the UK, demonstrating the effectiveness of DNA profiling in solving crimes and influencing its adoption worldwide.

+ Can you explain the Polymerase Chain Reaction (PCR) and its significance in DNA analysis? >

The Polymerase Chain Reaction (PCR) is a technique used to amplify small amounts of DNA into larger quantities, making it easier to analyze. PCR is significant in DNA analysis because it allows forensic scientists to obtain sufficient DNA from trace or degraded samples, facilitating accurate profiling and identification in forensic investigations.

+ What is Short Tandem Repeat (STR) analysis, and how is it employed in forensic DNA profiling? >

Short Tandem Repeat (STR) analysis involves examining specific regions of DNA where short sequences are repeated. In forensic DNA profiling, STRs are analyzed to create unique DNA profiles for individuals. This method is highly effective for distinguishing between individuals and matching DNA samples from crime scenes to suspects or victims.

+ What is forensic DNA testing? >

Forensic DNA testing involves analyzing biological samples, such as blood, hair, or saliva, to identify or verify the identity of individuals involved in criminal investigations. This method relies on the unique genetic profiles of individuals, which can be compared against DNA evidence found at crime scenes. Forensic DNA testing helps in linking suspects to crimes, exonerating the innocent, and identifying unknown victims. It plays a crucial role in modern criminal justice by providing reliable and precise evidence for solving cases and supporting legal proceedings.

+ What is the YSTR in DNA analysis? >

YSTR (Y-chromosome Short Tandem Repeat) analysis is a type of DNA testing that focuses on the Y chromosome, which is inherited paternally. YSTRs are specific regions on the Y chromosome that vary in length between individuals. This analysis is used in forensic investigations to trace paternal lineage, solve cases involving male-specific DNA evidence, and distinguish between male relatives. YSTR analysis is particularly useful in cases of sexual assault, paternity testing, and genealogical research, where it can provide insights into paternal ancestry and familial connections.

+ In what ways is forensic DNA analysis applied in crime scene investigations? >

Forensic DNA analysis is applied in crime scene investigations by identifying biological evidence such as blood, saliva, or semen, and comparing it to DNA profiles of suspects or victims. It helps link suspects to crime scenes, establish connections between evidence and individuals, and provide crucial evidence for solving cases and securing convictions.

+ What is the significance of forensic DNA analysis in paternity and relationship testing? >

Forensic DNA analysis is significant in paternity and relationship testing as it provides accurate genetic evidence to establish biological relationships. By comparing DNA profiles of individuals, forensic scientists can confirm or exclude potential parents, siblings, or other relatives, aiding in legal matters and personal identity verification.

+ How does DNA analysis contribute to solving missing persons and cold cases? >

DNA analysis contributes to solving missing persons and cold cases by providing a means to identify remains or link individuals to previously unsolved cases. By comparing DNA from recovered evidence or unidentified remains with DNA profiles in databases or from relatives, forensic scientists can make connections and resolve cases that have remained unresolved for years.

+ How is forensic DNA analysis utilized in mass disasters and humanitarian efforts? >

In mass disasters and humanitarian efforts, forensic DNA analysis is used to identify victims from large numbers of remains. It helps match DNA from unidentified bodies to family members, aiding in the recovery and identification process.

Controversies related to Forensic DNA Analysis

Privacy Concerns and DNA Databases: The use of DNA databases, whether for criminal investigations or commercial genetic testing services, raises significant privacy concerns. Individuals may unknowingly contribute their genetic information to databases, and the potential misuse of this data, such as unauthorized access or profiling, is a subject of ethical debate.

Racial and Ethnic Bias: There have been concerns about potential racial and ethnic bias in forensic DNA analysis. The representation of diverse populations in DNA databases is crucial to avoid disparities in the accuracy and fairness of results. In some cases, bias may arise due to the overrepresentation or underrepresentation of certain groups.

Familial DNA Searching: Familial DNA searching, where investigators search for partial matches that may indicate a familial relationship, has sparked controversy. Critics argue that it raises privacy concerns for innocent family members whose genetic information becomes part of criminal investigations without their consent.

False Positives and Contamination: The possibility of false positives in DNA analysis, either due to laboratory errors or contamination of samples, has been a source of controversy. A single mistake or contamination event can lead to inaccurate results, potentially impacting criminal investigations and legal proceedings.

Interpretation of Complex DNA Mixtures: Analyzing DNA mixtures from multiple individuals can be challenging, and the interpretation of complex mixtures is subject to controversy. Different laboratories may employ varying methods, leading to discrepancies in results and interpretations that can affect the outcome of legal cases.

Use of Rapid DNA Testing: The introduction of rapid DNA testing technologies has raised concerns about the potential misuse of this technology. Critics worry that law enforcement agencies may use rapid DNA testing in ways that compromise individual rights, such as conducting on-the-spot testing without proper oversight.

Genetic Genealogy and Privacy: The use of genetic genealogy to solve cold cases by identifying potential suspects through their relatives has sparked debates over privacy. The public availability of genetic information in online databases and the potential for unintended consequences for individuals who did not consent to their genetic data being used in criminal investigations are areas of concern.

Chain of Custody Issues: Maintaining the chain of custody for DNA evidence is crucial for its admissibility in court. Controversies may arise if there are lapses in the chain of custody, leading to questions about the reliability and integrity of the DNA samples.

Expert Testimony and Subjectivity: The interpretation of DNA evidence often involves expert testimony, and controversies may arise regarding the subjectivity of such interpretations. Critics argue that the subjective nature of expert testimony can introduce bias and affect the reliability of DNA analysis in court.

Post-Conviction DNA Testing and Innocence Projects: While post-conviction DNA testing has been instrumental in exonerating individuals who were wrongly convicted, controversies exist regarding the availability and accessibility of such testing. Some argue that bureaucratic obstacles and legal limitations can hinder efforts to revisit cases and correct miscarriages of justice.

Precautions to be used while using Forensic DNA Analysis

Preventing Contamination: Contamination is a significant risk in DNA analysis. Strict protocols should be followed to minimize the risk of introducing external DNA into samples. This includes using clean and sterile equipment, wearing protective gear, and working in designated, controlled environments.

Chain of Custody Documentation: Maintaining a clear and unbroken chain of custody for DNA samples is crucial. Proper documentation at each stage of the process, from collection to analysis, ensures the integrity of the evidence and enhances its admissibility in court.

Proper Collection Techniques: Collection of biological samples should be done using proper techniques to avoid degradation and contamination. Using sterile swabs, gloves, and other collection tools, as well as following established procedures, is essential to preserve the quality of the DNA.

Appropriate Sample Preservation: DNA samples should be preserved appropriately to prevent degradation over time. Preservation methods, such as refrigeration or freezing, should be selected based on the type of sample and the anticipated analysis timeline.

Use of Negative Controls: Negative controls, which are samples known not to contain DNA, should be included in each analysis batch. These controls help identify any contamination that may occur during the analytical process.

Validation and Quality Control: Laboratories conducting forensic DNA analysis should implement rigorous validation and quality control procedures. Regular testing of equipment, reagents, and methodologies ensures that the results are reliable and reproducible.

Training and Certification: Personnel involved in DNA analysis should undergo proper training and certification to ensure competence in handling samples and conducting analyses. Regular updates and continuing education are essential to stay abreast of new techniques and best practices.

Preventing Cross-Contamination: To prevent cross-contamination between samples, analysts must change gloves, clean work surfaces, and use disposable equipment for each new sample. Additionally, physical barriers, such as separate workstations, may be employed to minimize the risk of contamination.

Monitoring Environmental Factors: Environmental factors, such as temperature and humidity, can impact the stability of DNA samples. Laboratories should monitor and control these factors to ensure the optimal conditions for sample storage and analysis.

Documentation and Record Keeping: Thorough documentation of every step in the DNA analysis process is crucial. This includes recording the details of sample collection, extraction, amplification, and analysis. Comprehensive record-keeping facilitates transparency and allows for the verification of results.

Adherence to Standard Operating Procedures (SOPs): Laboratories should develop and strictly adhere to standard operating procedures (SOPs) for all aspects of DNA analysis. SOPs provide a standardized framework for conducting analyses, ensuring consistency and minimizing the risk of errors.

Adherence to Legal and Ethical Standards: Forensic scientists must adhere to legal and ethical standards in the collection and analysis of DNA evidence. Respecting individuals’ privacy rights, obtaining proper consent, and ensuring compliance with relevant laws are essential considerations.

Use of Blind Testing: Blind testing involves analyzing samples without knowledge of their origin or expected results. Implementing blind testing protocols helps minimize bias and ensures the objectivity of the analysis.

Regular Proficiency Testing: Laboratories should participate in regular proficiency testing programs to assess their performance and identify areas for improvement. External proficiency tests administered by independent organizations contribute to the ongoing validation of laboratory practices.

Communication and Collaboration: Effective communication and collaboration among forensic scientists, investigators, and legal professionals are vital. Clear communication ensures that the relevant information is conveyed accurately and that any challenges or uncertainties are addressed promptly.

Major Cases solved with help of Forensic DNA Analysis

The Golden State Killer (Joseph James DeAngelo): The Golden State Killer was a serial rapist and murderer who terrorized California in the 1970s and 1980s. Decades later, investigators used forensic DNA analysis to link crime scene DNA to distant relatives through a public genealogy database. This led to the identification and arrest of Joseph James DeAngelo in 2018.

The O.J. Simpson Murder Trial: The O.J. Simpson murder trial in 1995 involved the deaths of Nicole Brown Simpson and Ronald Goldman. DNA analysis of blood found at the crime scene, including samples from Simpson’s Ford Bronco and his residence, played a crucial role in the trial. The DNA evidence was a key factor in Simpson’s acquittal.

The Innocence Project Exonerations: The Innocence Project, a non-profit organization, has used DNA analysis to exonerate individuals who were wrongfully convicted. Notable cases include that of Kirk Bloodsworth, the first American on death row to be exonerated by DNA evidence in 1993, and Barry Scheck and Peter Neufeld, co-founders of the Innocence Project, have been involved in numerous other exonerations.

The West Memphis Three: The case of the West Memphis Three involved the wrongful conviction of three teenagers—Damien Echols, Jason Baldwin, and Jessie Misskelley—for the murders of three boys in West Memphis, Arkansas, in 1993. DNA evidence, analyzed years later, did not match the three defendants, leading to their release in 2011.

The Amanda Knox Case: The murder of Meredith Kercher in Italy in 2007 led to the arrest of Amanda Knox and her boyfriend Raffaele Sollecito. DNA evidence played a significant role in the trial. Subsequent re-analysis of the DNA evidence and concerns about its reliability led to the acquittal of Knox and Sollecito in 2015.

The Grim Sleeper (Lonnie David Franklin Jr.): Lonnie David Franklin Jr., known as the Grim Sleeper, was responsible for a series of murders in Los Angeles. Forensic DNA analysis linked Franklin to the crime scenes, ultimately leading to his arrest in 2010. He was convicted in 2016 for the murders of ten victims.

The Boston Strangler Case: Advances in forensic DNA analysis were applied to revisit the Boston Strangler case from the 1960s. In 2013, DNA evidence was used to confirm the identity of Albert DeSalvo as the perpetrator of one of the murders, providing closure to the victims’ families.

The Green River Killer (Gary Ridgway): Gary Ridgway, the Green River Killer, confessed to the murders of numerous women in the 1980s and 1990s. DNA evidence played a crucial role in linking him to the crimes, leading to his arrest in 2001. Ridgway pleaded guilty to 48 murders and was sentenced to life in prison without parole.

The D.C. Sniper Attacks (John Allen Muhammad and Lee Boyd Malvo): The D.C. sniper attacks in 2002 involved a series of shootings in the Washington, D.C., metropolitan area. Forensic analysis of ballistics and DNA evidence linked John Allen Muhammad and Lee Boyd Malvo to the crimes. The two were arrested, and Muhammad was executed in 2009, while Malvo received a life sentence without parole.

The Claremont Serial Killer (Bradley Robert Edwards): The Claremont Serial Killer case in Australia involved the murders of three young women in the 1990s. In 2019, Bradley Robert Edwards was convicted based on DNA evidence linking him to the crime scenes. The trial marked one of the longest and most complex in Australian history.

Facts on Forensic DNA Analysis

Mitochondrial DNA Analysis: In addition to nuclear DNA analysis, forensic scientists may analyze mitochondrial DNA. Mitochondrial DNA is inherited maternally and is often used in cases where nuclear DNA is degraded or limited. It is present in higher quantities and can be found in hair shafts and bones.

Familial DNA Searching: Familial DNA searching involves searching DNA databases for partial matches that may indicate a familial relationship. This technique has been employed to identify potential relatives of an unknown suspect.

Y-Chromosome Analysis: Y-chromosome analysis is particularly useful in cases where a male suspect is involved. This analysis focuses on the Y-chromosome, which is passed from father to son, and can be instrumental in establishing paternal relationships.

CODIS (Combined DNA Index System): CODIS is a national DNA database in the United States that allows law enforcement agencies to share and compare DNA profiles. It contains DNA profiles from convicted offenders, crime scenes, and missing persons.

DNA Phenotyping: DNA phenotyping is an emerging technique that predicts physical traits such as eye color, hair color, and facial structure based on DNA. While still in the developmental stage, it holds potential for generating suspect descriptions from DNA evidence.

Post-Conviction DNA Testing: Post-conviction DNA testing involves re-examining DNA evidence in cases where advancements in technology may provide new insights or when there are doubts about the guilt of a convicted individual.

International Cooperation: Forensic DNA databases are increasingly becoming part of international cooperation efforts. Countries share DNA information to assist in cross-border criminal investigations and to combat transnational crimes.

Genetic Genealogy: Genetic genealogy involves using DNA databases and genealogical records to trace familial relationships. It has been instrumental in solving cold cases by identifying potential suspects through their relatives.

Forensic Entomology and DNA: In certain cases, forensic entomology, the study of insects, can be combined with DNA analysis. Insects found on a body can provide valuable information about the time of death, and DNA analysis can be used to identify the species.

DNA Preservation Techniques: Various techniques, such as refrigeration and the use of preservatives, are employed to preserve DNA samples. Proper preservation is crucial for maintaining the integrity of DNA evidence over time.

Amelogenin Gene for Gender Determination: The amelogenin gene on the X and Y chromosomes can be targeted to determine the gender of an individual. This is often used to confirm the sex of a suspect or victim when analyzing DNA samples.

Forensic DNA Ethics Committees: Some jurisdictions have established ethics committees to address the ethical implications of forensic DNA analysis, ensuring responsible and unbiased practices in the collection and use of DNA evidence.

Academic references on Forensic DNA Analysis

  1. Butler, J. M. (2005). Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers (2nd ed.). Academic Press.
  2. Goodwin, W., & Linacre, A. (2011). Forensic DNA Evidence Interpretation (2nd ed.). CRC Press.
  3. Kayser, M., & Ballantyne, K. N. (2015). Principles and Practice of Forensic DNA Typing. Academic Press.
  4. Butler, J. M. (2015). Advanced Topics in Forensic DNA Typing: Interpretation (1st ed.). Academic Press.
  5. Butler, J. M. (2015). Advanced Topics in Forensic DNA Typing: Methodology (1st ed.). Academic Press.
  6. Holland, M. M. (2007). Forensic DNA Typing Protocols (Methods in Molecular Biology). Humana Press.
  7. Linacre, A., & Gusmão, L. (Eds.). (2016). Forensic DNA Applications: An Interdisciplinary Perspective. CRC Press.
  8. Buckleton, J. S., Triggs, C. M., & Walsh, S. J. (Eds.). (2005). Forensic DNA Evidence Interpretation (1st ed.). CRC Press.
  9. Carracedo, Á., & Brinkmann, B. (Eds.). (2005). Progress in Forensic Genetics 10: Proceedings of the 20th International ISFG Congress Held in Arcachon, France Between 9 and 13 September 2003. Elsevier.
  10. Jobling, M. A., & Gill, P. (Eds.). (2004). Encyclopedia of Forensic and Legal Medicine. Academic Press.
  11. Budowle, B., & Moretti, T. R. (2005). Forensic aspects of mass disasters: Strategic considerations for DNA-based human identification. Legal Medicine, 7(4), 230–243.
  12. Pääbo, S. (2004). Ancient DNA: Extraction, characterization, molecular cloning, and enzymatic amplification. Proceedings of the National Academy of Sciences, 86(6), 1939–1943.
  13. Jobling, M. A., & Gill, P. (Eds.). (2005). Encyclopedia of Forensic and Legal Medicine. Elsevier Academic Press.
  14. Foreman, L. A., & Evett, I. W. (2006). Some issues in forensic interpretation: A response to Dr. Balding’s paper on weight of evidence. Science & Justice, 46(1), 33–35.

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